Genomic loss of patient-specific HLA in acute myeloid leukemia relapse after well-matched unrelated donor HSCT.

Abstract

1. Ayyoub M, Raffin C, Valmori D. Generation of Th17 from human naive CD4 T cells preferentially occurs from FOXP3 Tregs upon costimulation via CD28 or CD5 [letter]. Blood. 2012;119(20):4810-4812. 2. de Wit J, Souwer Y, van Beelen AJ, et al. CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation. Blood. 2011;118(23):6107-6114. 3. Zhou L, Ivanov II, Spolski R, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8(9):967-974. 4. Nishihara M, Ogura H, Ueda N, et al. IL-6-gp130-STAT3 in T cells directs the development of IL-17 Th with a minimum effect on that of Treg in the steady state. Int Immunol. 2007;19(6):695-702. 5. Oberg HH, Wesch D, Grussel S, Rose-John S, Kabelitz D. Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4 CD25 and CD25high regulatory T cells. Int Immunol. 2006;18(4):555563.

DOI: 10.1182/blood-2012-02-411686

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@article{Toffalori2012GenomicLO, title={Genomic loss of patient-specific HLA in acute myeloid leukemia relapse after well-matched unrelated donor HSCT.}, author={Cristina Toffalori and Irene Maria Cavattoni and Sara Deola and Sara Mastaglio and Fabio Giglio and Benedetta Mazzi and Andrea P. Assanelli and Jacopo Peccatori and Claudio Bordignon and Chiara Bonini and Sergio Cortelazzo and Fabio Ciceri and Katharina Fleischhauer and Luca Vago}, journal={Blood}, year={2012}, volume={119 20}, pages={4813-5} }