Genomic landscape of lymphoepithelioma‐like hepatocellular carcinoma

@article{Chan2019GenomicLO,
  title={Genomic landscape of lymphoepithelioma‐like hepatocellular carcinoma},
  author={Anthony Wing-Hung Chan and Zhe Zhang and Charing Ching-Ning Chong and Edith Ka-Yee Tin and Chit Chow and Nathalie Wong},
  journal={The Journal of Pathology},
  year={2019},
  volume={249}
}
Lymphoepithelioma‐like hepatocellular carcinoma (LEL‐HCC) is a distinct variant of HCC that is characterized by dense tumor‐infiltrating lymphocytes (TILs). Patients with LEL‐HCC also show better clinical outcomes compared to conventional HCC (c‐HCC), which is commonly presented with low TIL. Emerging evidence has begun to highlight tumor‐intrinsic genetic abnormalities in the tumor–host immune interfaces. However, genome‐wide characterization of LEL‐HCC remains largely unexplored. Here, we… 
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma
TLDR
EBV-associated LELCs from different organs were more similar to each other genetically as compared with other traditional carcinomas of the same sites -as evidenced by unsupervised clustering based on the quantitative data from both mutation signature and chromosomal aneuploidies.
Checkpoint Inhibition in the Treatment of Unresectable, Advanced Lymphoepithelioma-like Hepatocellular Carcinoma
TLDR
The case of a 68 year-old man with unresectable, advanced LEL-HCC who had evidence of disease stability after starting on the immune checkpoint inhibitor nivolumab is reported on.
Lymphoepithelioma-like Intrahepatic Cholangiocarcinoma Is a Distinct Entity With Frequent pTERT/TP53 Mutations and Comprises 2 Subgroups Based on Epstein-Barr Virus Infection
TLDR
The molecular characteristics of lymphoepithelioma-like intrahepatic cholangiocarcinoma (LELCC) remain elusive and next-generation sequencing demonstrated that EBER- LELCC was significantly associated with pTERT and TP53 mutations, which has implications for potential immunotherapeutic strategies.
An update on the histological subtypes of hepatocellular carcinoma
  • R. Lo
  • Medicine, Biology
  • 2019
TLDR
Further delineation of the histological, immunohistochemical, molecular and biological phenotypes of primary liver cancer would to further enhance an integrated morphological-molecular classification that better predicts clinical outcome and guides clinical management.
Pathologic and molecular features of hepatocellular carcinoma: An update
TLDR
This manuscript reviews the recently identified histomorphological subtypes and molecular alterations in HCC and suggests that the reporting of subtypes may be quite useful for personalized therapeutic purpose.
Pathomolecular characterization of HCC in non-cirrhotic livers
TLDR
An update of etiology, patho-molecular characteristics and differential diagnosis of HCC arising in non-cirrhotic backgrounds is offered.
Hepatocellular Carcinoma: A Pharmacological Aspect
TLDR
It is aimed to focus such pharmacological aspects in HCC treatment that could effectively display the improved therapies and result obtained could be a magnificent approach in the advancement of drug delivery systems that could assist in clinical trials and further betterment of survival rate and improved therapy from this deadly cancer.
Evaluating tumor-infiltrating lymphocytes in hepatocellular carcinoma using hematoxylin and eosin-stained tumor sections
TLDR
HCC patients with high infiltrating lymphocytes tend to have a lower recurrence rate and less MVI, and the evaluation of TILs in H&E-stained specimens could be a prognostic parameter for HCC.
...
...

References

SHOWING 1-10 OF 32 REFERENCES
Lessons from rare tumors: hepatic lymphoepithelioma-like carcinomas.
TLDR
Compared with classical hepatocellular carcinoma and intrahepatic cholangiocarcinoma of corresponding stage, both L EL-HCC and LEL-ICC are characterized by lower rates of recurrence after surgery and better overall survival.
Lymphoepithelioma-Like Carcinoma in Liver.
Lymphoepithelioma-like hepatocellular carcinoma
TLDR
This case was the youngest patient of all the reported cases, and the third case who was infected with both hepatitis B virus (HBV) and hepatitis C virus (HCV).
Lymphoepithelioma-like Hepatocellular Carcinoma: An Uncommon Variant of Hepatocellular Carcinoma With Favorable Outcome
  • A. ChanJ. Tong K. To
  • Medicine, Biology
    The American journal of surgical pathology
  • 2015
TLDR
The multivariate analysis revealed that LEL-HCC was an independent prognostic factor for overall and progression-free survivals and a distinct uncommon variant of HCC characterized by dense cytotoxic T-cell infiltration and favorable prognosis.
Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature.
TLDR
The clinicopathological features of the case are reported, along with a review of the few cases present in the literature, to report on the synchronous occurrence of HCC and GIST.
Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma
TLDR
Palbociclib shows encouraging results in preclinical models of HCC and represents a novel therapeutic strategy for HCC treatment, alone or particularly in combination with sorafenib.
Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
TLDR
Evaluation of whole-exome sequencing on micro-dissected EBV-positive NPCs found enrichment for genomic aberrations of multiple negative regulators of the NF-κB pathway, including CYLD, TRAF3, NFKBIA and NLRC5, in a total of 41% of cases, suggesting that NF-γB activation is selected for by both somatic and viral events during NPC pathogenesis.
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
TLDR
A combination of hotspot TERT promoter mutation, TERT focal amplification and viral genome integration occurs in more than 68% of cases, implicating TERT as a central and ancestry-independent node of hepatocarcinogenesis.
...
...