Genomic landscape of lymphoepithelioma‐like hepatocellular carcinoma
@article{Chan2019GenomicLO, title={Genomic landscape of lymphoepithelioma‐like hepatocellular carcinoma}, author={Anthony Wing-Hung Chan and Zhe Zhang and Charing Ching-Ning Chong and Edith Ka-Yee Tin and Chit Chow and Nathalie Wong}, journal={The Journal of Pathology}, year={2019}, volume={249} }
Lymphoepithelioma‐like hepatocellular carcinoma (LEL‐HCC) is a distinct variant of HCC that is characterized by dense tumor‐infiltrating lymphocytes (TILs). Patients with LEL‐HCC also show better clinical outcomes compared to conventional HCC (c‐HCC), which is commonly presented with low TIL. Emerging evidence has begun to highlight tumor‐intrinsic genetic abnormalities in the tumor–host immune interfaces. However, genome‐wide characterization of LEL‐HCC remains largely unexplored. Here, we…
21 Citations
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References
SHOWING 1-10 OF 32 REFERENCES
Lessons from rare tumors: hepatic lymphoepithelioma-like carcinomas.
- Medicine, BiologyWorld journal of gastroenterology
- 2015
Compared with classical hepatocellular carcinoma and intrahepatic cholangiocarcinoma of corresponding stage, both L EL-HCC and LEL-ICC are characterized by lower rates of recurrence after surgery and better overall survival.
Lymphoepithelioma-Like Carcinoma in Liver.
- Medicine, BiologyThe American journal of pathology
- 2017
Lymphoepithelioma-like hepatocellular carcinoma
- Medicine, BiologyMedicine
- 2017
This case was the youngest patient of all the reported cases, and the third case who was infected with both hepatitis B virus (HBV) and hepatitis C virus (HCV).
Lymphoepithelioma-like Hepatocellular Carcinoma: An Uncommon Variant of Hepatocellular Carcinoma With Favorable Outcome
- Medicine, BiologyThe American journal of surgical pathology
- 2015
The multivariate analysis revealed that LEL-HCC was an independent prognostic factor for overall and progression-free survivals and a distinct uncommon variant of HCC characterized by dense cytotoxic T-cell infiltration and favorable prognosis.
Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature.
- MedicineWorld journal of gastroenterology
- 2015
The clinicopathological features of the case are reported, along with a review of the few cases present in the literature, to report on the synchronous occurrence of HCC and GIST.
Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma
- Biology, MedicineGut
- 2017
Palbociclib shows encouraging results in preclinical models of HCC and represents a novel therapeutic strategy for HCC treatment, alone or particularly in combination with sorafenib.
Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
- Biology, MedicineNature communications
- 2017
Evaluation of whole-exome sequencing on micro-dissected EBV-positive NPCs found enrichment for genomic aberrations of multiple negative regulators of the NF-κB pathway, including CYLD, TRAF3, NFKBIA and NLRC5, in a total of 41% of cases, suggesting that NF-γB activation is selected for by both somatic and viral events during NPC pathogenesis.
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
- BiologyNature Genetics
- 2014
A combination of hotspot TERT promoter mutation, TERT focal amplification and viral genome integration occurs in more than 68% of cases, implicating TERT as a central and ancestry-independent node of hepatocarcinogenesis.
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
- Biology, MedicineCell
- 2015