Genomic landscape of DNA repair genes in cancer

  title={Genomic landscape of DNA repair genes in cancer},
  author={Young Kwang Chae and Jonathan F Anker and Benedito A. Carneiro and Sunandana Chandra and Jason Benjamin Kaplan and Aparna Kalyan and Cesar Augusto Santa-Maria and Leonidas C. Platanias and Francis J Giles},
DNA repair genes are frequently mutated in cancer, yet limited data exist regarding the overall genomic landscape and functional implications of these alterations in their entirety. We created comprehensive lists of DNA repair genes and indirect caretakers. Mutation, copy number variation (CNV), and expression frequencies of these genes were analyzed in COSMIC. Mutation co-occurrence, clinical outcomes, and mutation burden were analyzed in TCGA. We report the 20 genes most frequently with… CONTINUE READING
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