Genomic island 2 of Brucella melitensis is a major virulence determinant: functional analyses of genomic islands.

@article{Rajashekara2008GenomicI2,
  title={Genomic island 2 of Brucella melitensis is a major virulence determinant: functional analyses of genomic islands.},
  author={Gireesh Rajashekara and Jill C Covert and Erik Petersen and Linda Eskra and Gary Splitter},
  journal={Journal of bacteriology},
  year={2008},
  volume={190 18},
  pages={6243-52}
}
Brucella genomic islands (GIs) share similarities in their genomic organization to pathogenicity islands from other bacteria and are likely acquired by lateral gene transfer. Here, we report the identification of a GI that is important for the pathogenicity of Brucella melitensis. The deletion of GI-1, GI-5, or GI-6 did not affect bacterial growth in macrophages as well as their virulence in interferon regulatory factor 1-deficient (IRF-1(-/-)) mice, suggesting that these islands do not… CONTINUE READING
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