Genomic instability of the DYZ1 repeat in patients with Y chromosome anomalies and males exposed to natural background radiation.

@article{Pathak2006GenomicIO,
  title={Genomic instability of the DYZ1 repeat in patients with Y chromosome anomalies and males exposed to natural background radiation.},
  author={Deepali Pathak and Sanjay Premi and Jyoti Bhushan Srivastava and Sebastian Padinjarel Chandy and Safdar Ali},
  journal={DNA research : an international journal for rapid publication of reports on genes and genomes},
  year={2006},
  volume={13 3},
  pages={103-9}
}
We assessed genomic instability of 3.4 kb DYZ1 repeat arrays in patients encompassing prostate cancer (PC), cases of repeated abortion (RA) and males exposed to natural background radiation (NBR) using real-time PCR and fluorescence in situ hybridization (FISH). Normal males showed DYZ1 copies ranging from 3000 to 4300, RA, 0-2237; PC, 550; and males exposed to NBR, 1577-5700. FISH showed organizational variation of DYZ1 in these samples substantiating the data obtained from real-time PCR. Of… CONTINUE READING

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