Genomic instability in the breast microenvironment? A critical evaluation of the evidence.

@article{Holliday2009GenomicII,
  title={Genomic instability in the breast microenvironment? A critical evaluation of the evidence.},
  author={Charvonne Holliday and Seth K. Rummel and Jeffrey A. Hooke and Craig D. Shriver and Darrell L Ellsworth and Rachel E. Ellsworth},
  journal={Expert review of molecular diagnostics},
  year={2009},
  volume={9 7},
  pages={667-78}
}
Tumor-associated stroma plays an active role in breast pathogenesis, with alterations in cell signaling, proliferation and angiogenesis contributing to successful tumorigenesis. Although epigenetic modifications to DNA, as well as changes in RNA and protein expression have been identified in tumor-associated stroma, there is considerable debate regarding… CONTINUE READING