Genomic instability in human osteoblast cells after exposure to depleted uranium: delayed lethality and micronuclei formation.

@article{Miller2003GenomicII,
  title={Genomic instability in human osteoblast cells after exposure to depleted uranium: delayed lethality and micronuclei formation.},
  author={Alexandra C Miller and Kia Brooks and Michael Stewart and Blake Harrell Anderson and Lin Shi and David W. McClain and N. Page},
  journal={Journal of environmental radioactivity},
  year={2003},
  volume={64 2-3},
  pages={
          247-59
        }
}
It is known that radiation can induce a transmissible persistent destabilization of the genome. We have established an in vitro cellular model using HOS cells to investigate whether genomic instability plays a role in depleted uranium (DU)-induced effects. Transmissible genomic instability, manifested in the progeny of cells exposed to ionizing radiation, has been characterized by de novo chromosomal aberrations, gene mutations, and an enhanced death rate. Cell lethality and micronuclei… CONTINUE READING
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