Genomic instability and cancer.

@article{Charames2003GenomicIA,
  title={Genomic instability and cancer.},
  author={G Charames and Bharati Bapat},
  journal={Current molecular medicine},
  year={2003},
  volume={3 7},
  pages={
          589-96
        }
}
Tumorigenesis can be viewed as an imbalance between the mechanisms of cell-cycle control and mutation rates within the genes. Genomic instability is broadly classified into microsatellite instability (MIN) associated with mutator phenotype, and chromosome instability (CIN) recognized by gross chromosomal abnormalities. Three intracellular mechanisms are involved in DNA damage repair that leads to mutator phenotype. They include the nucleotide excision repair (NER), base excision repair (BER… CONTINUE READING
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