Genomic instability: Suppressing CIN promotes growth

  title={Genomic instability: Suppressing CIN promotes growth},
  author={Gemma K. Alderton},
  journal={Nature Reviews Cancer},
Valencia et al. investigated the role of p62 in tumourassociated stromal cells, in which its expression is frequently reduced in tumour samples. The growth of prostate cancer cells in syngeneic p62-knockout mice was significantly increased compared to growth in control mice. p62 loss in cancer-associated fibroblasts led to increased expression of… CONTINUE READING