Genomic instability, mutators, and the development of cancer: is there a role for p53?

@article{Fishel1996GenomicIM,
  title={Genomic instability, mutators, and the development of cancer: is there a role for p53?},
  author={Richard Fishel},
  journal={Journal of the National Cancer Institute},
  year={1996},
  volume={88 22},
  pages={1608-9}
}
  • Richard Fishel
  • Published 1996 in Journal of the National Cancer Institute
The concept that multiple mutations occur in the development of tumors was first discussed by Fisher and Holloman (7) in 1951, and it has acquired numerous modifications over the past 40 years (2). These modifications have included the idea of tumor clonality (3), the requirement of at least two mutations to uncover tumor suppressor genes {4,5), and the identification of mutation "pathways" in developing tumors (6). The description of tumorigenesis pathways that require six or more gene… CONTINUE READING

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p 53 protein exhibits 3 'to5 ' exonuclease activity

T Mummenbrauer, F Janus, +3 authors F Grosse
Proc Natl Acad Sci U S A • 1994

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

Proceedings of the National Academy of Sciences of the United States of America • 1994

A mammalian cell cycle checkpoint pathway utilizing p 53 and GADD 45 is defective in ataxiatelangiectasia

MB Kastan, Q Zhan, +3 authors WV Walsh
cancer cells Cell • 1992

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