Genomic insights into tuberculosis

@article{Galagan2014GenomicII,
  title={Genomic insights into tuberculosis},
  author={James E. Galagan},
  journal={Nature Reviews Genetics},
  year={2014},
  volume={15},
  pages={307-320}
}
  • J. Galagan
  • Published 1 May 2014
  • Biology, Medicine
  • Nature Reviews Genetics
Prevalent since pre-history, human tuberculosis — caused by the pathogen Mycobacterium tuberculosis — remains a major source of death worldwide. Moreover, increasing drug resistance poses the threat of disease resurgence. However, the expanding application of genomic techniques is providing new avenues for combating this old foe. Whole-genome sequencing, comparative genomics and systems biology are generating new insights into the origins and ongoing evolution of M. tuberculosis, as well as the… 
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The applications of clustered regularly interspaced short palindromic repeat interference (CRISPRi), a novel technology recently applied in M. tuberculosis research to study target gene functions, are discussed.
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