Genomic insights into the population structure and history of the Irish Travellers

@article{Gilbert2017GenomicII,
  title={Genomic insights into the population structure and history of the Irish Travellers},
  author={Edmund Gilbert and Shai Carmi and Sean Ennis and James F. Wilson and Gianpiero L. Cavalleri},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
The Irish Travellers are a population with a history of nomadism; consanguineous unions are common and they are socially isolated from the surrounding, ‘settled’ Irish people. Low-resolution genetic analysis suggests a common Irish origin between the settled and the Traveller populations. What is not known, however, is the extent of population structure within the Irish Travellers, the time of divergence from the general Irish population, or the extent of autozygosity. Using a sample of 50… 

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References

SHOWING 1-10 OF 37 REFERENCES

Genetic drift and the population history of the Irish travellers.

TLDR
After adjustment for the expected effects of genetic drift, the Travellers are equidistant from the other Irish samples, showing their Irish origins and population history, and there is no evidence of any external gene flow.

The origins of the Irish travellers and the genetic structure of Ireland.

TLDR
The objectives of this study were to determine the genetic affinity of the Travellers to the general Irish population based on gene frequency data, subdivided by county, and to explore the relationship between subpopulations of Ireland, given its turbulent history.

People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population

TLDR
The collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population.

The fine-scale genetic structure of the British population

TLDR
There is significant pre-Roman but post-Mesolithic movement into southeastern England from continental Europe, and it is shown that in non-Saxon parts of the United Kingdom, there exist genetically differentiated subgroups rather than a general ‘Celtic’ population.

Genomic Runs of Homozygosity Record Population History and Consanguinity

TLDR
Genome-wide analysis of long and shorter ROH allows categorisation of the mainly indigenous populations sampled here into four major groups in which the majority of the population are inferred to have: recent parental relatedness (south and west Asians), shared parental ancestry arising hundreds to thousands of years ago through long term isolation and restricted effective population size (Ne), but little recent inbreeding (Oceanians), and the occasional cryptically inbred individual.

Genotyping of geographically diverse Druze trios reveals substructure and a recent bottleneck

TLDR
Principal component (PC) and ADMIXTURE analyses demonstrated that Druze are close to, yet distinct from, other Middle-Eastern groups (Bedouins and Palestinians), supporting the Druze’s Middle- Eastern origin and their recent genetic isolation.

Ancient Admixture in Human History

TLDR
A suite of methods for learning about population mixtures are presented, implemented in a software package called ADMIXTOOLS, that support formal tests for whether mixture occurred and make it possible to infer proportions and dates of mixture.

Rare metabolic diseases among the Irish travellers: results from the All Ireland Traveller Health Study census and birth cohort (2007-2011)

TLDR
There is a limited newborn screening service in the Republic of Ireland; given the higher prevalence of these metabolic diseases among the Travellers, a Traveller-specific prevention strategy should be considered.

Genetic basis of transferase-deficient galactosaemia in Ireland and the population history of the Irish Travellers

TLDR
The Q188R mutation was shown to be in linkage disequilibrium with a Sac I RFLP flanking exon 6 of the GALT gene and represents the first molecular genetic description of classical transferase-deficient galactosaemia in Ireland and raises intriguing questions concerning the genetic history of the Irish Travellers.