Genomic insights into WNT/β-catenin signaling.

@article{Rosenbluh2014GenomicII,
  title={Genomic insights into WNT/β-catenin signaling.},
  author={Joseph Rosenbluh and Xiaoxing Wang and William C. Hahn},
  journal={Trends in pharmacological sciences},
  year={2014},
  volume={35 2},
  pages={103-9}
}
The canonical WNT pathway regulates the stability of the proto-oncogene β-catenin and is aberrantly activated in many cancer types. Studies in a wide range of experimental models confirm that β-catenin activity is required for tumor initiation in cancers where this pathway is deregulated. However, to date this pathway has proven to be challenging to target therapeutically. Moreover, several lines of evidence suggest that other components and regulators of β-catenin exist. Here we will describe… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Crosstalk between long non‐coding RNAs and Wnt/β‐catenin signalling in cancer

Journal of cellular and molecular medicine • 2018
View 1 Excerpt

Glucosamine promotes chondrocyte proliferation via the Wnt/β-catenin signaling pathway

International journal of molecular medicine • 2018
View 1 Excerpt

Role of DKK4 in Tumorigenesis and Tumor Progression

International journal of biological sciences • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth.

Proceedings of the National Academy of Sciences of the United States of America • 2013

WNT10B/b-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer

P Wend
EMBO Mol. Med • 2013

CDX2 is an amplified lineage-survival oncogene in colorectal cancer.

Proceedings of the National Academy of Sciences of the United States of America • 2012

Similar Papers

Loading similar papers…