Genomic imprinting: parental influence on the genome

@article{Reik2001GenomicIP,
  title={Genomic imprinting: parental influence on the genome},
  author={Wolf Reik and J{\"o}rn Walter},
  journal={Nature Reviews Genetics},
  year={2001},
  volume={2},
  pages={21-32}
}
Genomic imprinting affects several dozen mammalian genes and results in the expression of those genes from only one of the two parental chromosomes. This is brought about by epigenetic instructions — imprints — that are laid down in the parental germ cells. Imprinting is a particularly important genetic mechanism in mammals, and is thought to influence the transfer of nutrients to the fetus and the newborn from the mother. Consistent with this view is the fact that imprinted genes tend to… 
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A group of small imprinted domains, which consist of paternally expressed genes embedded within introns of multiexonic transcripts, are focused on to discuss the evolution of imprinting at these loci.
The role of imprinted genes in humans.
TLDR
The role of imprinted genes in fetal growth will be explored by investigating their relationship to a common growth disorder, intrauterine growth restriction (IUGR) and also their potential role in regulating normal growth variation.
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TLDR
The first steps for understanding the functions of DNA methylation and its regulation in mammalian development have led to identify common genetic mechanisms involved in the eight human congenital imprinting disorders.
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TLDR
This review of genomic imprinting focuses on the recent discoveries on the mechanisms involved in the reprogramming and maintenance of the imprints and discusses the epigenetic changes that occur at imprinted loci in induced pluripotent stem cells.
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