Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells.

@article{Joos2000GenomicII,
  title={Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells.},
  author={Stefan Joos and Monika K{\"u}pper and Sybille Ohl and Frederike von Bonin and Gunhild Mechtersheimer and Martin Bentz and Peter Marynen and Peter L Moeller and Michael Pfreundschuh and Lorenz H. Tr{\"u}mper and Peter Lichter},
  journal={Cancer research},
  year={2000},
  volume={60 3},
  pages={549-52}
}
Comparative genomic hybridization was applied for a comprehensive screening of frequently occurring net gains and losses of chromosomal subregions in small populations of CD30+ Hodgkin cells and their morphological variants. In 12 Hodgkin's lymphomas, recurrent gains were detected on chromosomal arms 2p, 9p, and 12q (in six, four, and five tumors, respectively) and distinct high-level amplifications were identified on chromosomal bands 4p16, 4q23-q24, and 9p23-p24. In Hodgkin cells with 9p23… CONTINUE READING

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