Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice.

@article{Welch2006GenomicIO,
  title={Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice.},
  author={Kevin D Welch and Timothy P. Reilly and Mohammed Bourdi and Thomas Hays and Cynthia A. Pise-Masison and Michael F. Radonovich and John N. Brady and David J. Dix and Lance R. Pohl},
  journal={Chemical research in toxicology},
  year={2006},
  volume={19 2},
  pages={223-33}
}
Drug-induced liver disease (DILD) continues to cause significant morbidity and mortality and impair new drug development. Mounting evidence suggests that DILD is a complex, multifactorial disease in which no one factor is likely to be an absolute indicator of susceptibility. As an approach to better understand the multifactorial basis of DILD, we recently compared the hepatic proteomes of mice that were resistant (SJL) and susceptible (C57Bl/6) to APAP-induced liver disease (AILD) wherein we… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer.

Toxicological sciences : an official journal of the Society of Toxicology • 2008
View 3 Excerpts
Highly Influenced

Role of Osteopontin in Liver Diseases

International journal of biological sciences • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…