Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma.

@article{Woenckhaus2002GenomicGO,
  title={Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma.},
  author={Joachim Woenckhaus and Klaus Steger and Emmy E. Werner and Irina Fenic and Ulrike Gamerdinger and Thomas Dreyer and Ulrich Stahl},
  journal={The Journal of pathology},
  year={2002},
  volume={198 3},
  pages={
          335-42
        }
}
PIK3CA, encoding the catalytic subunit p110alpha of phosphatidylinositol 3-kinase (PI3K), is activated in malignant diseases. However, the role of the PIK3CA gene aberrations for tumourigenesis of head and neck squamous cell carcinoma (HNSCC) is to date unclear. The present study was designed to determine the genomic aberration of PIK3CA in invasive HNSCC and dysplastic precursor lesions by fluorescence in situ hybridization (FISH) with a YAC probe, containing the PIK3CA gene, on isolated… CONTINUE READING
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