Genomic footprinting

@article{Vierstra2016GenomicF,
  title={Genomic footprinting},
  author={Jeff Vierstra and John A. Stamatoyannopoulos},
  journal={Nature Methods},
  year={2016},
  volume={13},
  pages={213-221}
}
The advent of DNA footprinting with DNase I more than 35 years ago enabled the systematic analysis of protein-DNA interactions, and the technique has been instrumental in the decoding of cis-regulatory elements and the identification and characterization of transcription factors and other DNA-binding proteins. The ability to analyze millions of individual genomic cleavage events via massively parallel sequencing has enabled in vivo DNase I footprinting on a genomic scale, offering the potential… CONTINUE READING
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