Genomic footprinting

  title={Genomic footprinting},
  author={Jeff Vierstra and John A. Stamatoyannopoulos},
  journal={Nature Methods},
The advent of DNA footprinting with DNase I more than 35 years ago enabled the systematic analysis of protein-DNA interactions, and the technique has been instrumental in the decoding of cis-regulatory elements and the identification and characterization of transcription factors and other DNA-binding proteins. The ability to analyze millions of individual genomic cleavage events via massively parallel sequencing has enabled in vivo DNase I footprinting on a genomic scale, offering the potential… CONTINUE READING
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Integrative analysis of 111 reference human epigenomes

  • J. Kähärä, H. Lähdesmäki
  • Nature
  • 2015

Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape

  • R. I. Sherwood
  • Nat . Biotechnol .
  • 2014

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