Genomic diversity and fitness of E. coli strains recovered from the intestinal and urinary tracts of women with recurrent urinary tract infection.

@article{Chen2013GenomicDA,
  title={Genomic diversity and fitness of E. coli strains recovered from the intestinal and urinary tracts of women with recurrent urinary tract infection.},
  author={Swaine L Chen and Meng Qi Yelena Wu and Jeffrey P. Henderson and Thomas M. Hooton and Michael E Hibbing and Scott J Hultgren and Jeffrey I. Gordon},
  journal={Science translational medicine},
  year={2013},
  volume={5 184},
  pages={184ra60}
}
Urinary tract infections (UTIs) are common in women, and recurrence is a major clinical problem. Most UTIs are caused by uropathogenic Escherichia coli (UPEC). UPEC are generally thought to migrate from the gut to the bladder to cause UTI. UPEC form specialized intracellular bacterial communities in the bladder urothelium as part of a pathogenic mechanism to establish a foothold during acute stages of infection. Evolutionarily, such a specific adaptation to the bladder environment would be… CONTINUE READING
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