Genomic deletions and precise removal of transposable elements mediated by short identical DNA segments in primates.

@article{Lagemaat2005GenomicDA,
  title={Genomic deletions and precise removal of transposable elements mediated by short identical DNA segments in primates.},
  author={Louie N. van de Lagemaat and Liane Gagnier and Patrik Medstrand and Dixie L. Mager},
  journal={Genome research},
  year={2005},
  volume={15 9},
  pages={
          1243-9
        }
}
Insertion of transposable elements is a major cause of genomic expansion in eukaryotes. Less is understood, however, about mechanisms underlying contraction of genomes. In this study, we show that retroelements can, in rare cases, be precisely deleted from primate genomes, most likely via recombination between 10- to 20-bp target site duplications (TSDs) flanking the retroelement. The deleted loci are indistinguishable from pre-integration sites, effectively reversing the insertion. Through… CONTINUE READING
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