Genomic cloning of the rat histamine H1 receptor.

  title={Genomic cloning of the rat histamine H1 receptor.},
  author={Kohei Fujimoto and Yoshiyuki Horio and Ketut Sugama and Satoru Ito and Yinghui Liu and Hirokazu Fukui},
  journal={Biochemical and biophysical research communications},
  volume={190 1},
A rat histamine H1 receptor gene which lacked introns was isolated from a rat genomic library using recently cloned bovine histamine H1 receptor cDNA [Yamashita et al., Proc. Natl. Acad. Sci. USA, 88, 11515-11519 (1991)]. The receptor protein deduced from this isolated gene was composed of 486 amino acids and showed characteristic properties of G protein-coupled receptors. At the 5'-flanking region of the receptor gene, we have located potential TATA box sequences and consensus sequences for… CONTINUE READING


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