Genomic classifier identifies men with adverse pathology after radical prostatectomy who benefit from adjuvant radiation therapy.

@article{Den2015GenomicCI,
  title={Genomic classifier identifies men with adverse pathology after radical prostatectomy who benefit from adjuvant radiation therapy.},
  author={Robert B Den and Kasra Yousefi and Edouard John Trabulsi and Firas Abdollah and Voleak Choeurng and Felix Feng and Adam Dicker and Costas D. Lallas and Leonard G. Gomella and Elai Davicioni and Robert Jeffrey Karnes},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2015},
  volume={33 8},
  pages={944-51}
}
PURPOSE The optimal timing of postoperative radiotherapy (RT) after radical prostatectomy (RP) is unclear. We hypothesized that a genomic classifier (GC) would provide prognostic and predictive insight into the development of clinical metastases in men receiving post-RP RT and inform decision making. PATIENTS AND METHODS GC scores were calculated from 188 patients with pT3 or margin-positive prostate cancer, who received post-RP RT at Thomas Jefferson University and Mayo Clinic between 1990… CONTINUE READING
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