Genomic chondrocyte culture profiling by array-CGH, interphase-FISH and RT-PCR.

@article{Stumm2012GenomicCC,
  title={Genomic chondrocyte culture profiling by array-CGH, interphase-FISH and RT-PCR.},
  author={Markus Stumm and Eliahu Boger and Christoph Gaissmaier and Claudia Osswald and Markus Blankenburg and R D Wegner and J{\"u}rgen A. Mollenhauer},
  journal={Osteoarthritis and cartilage},
  year={2012},
  volume={20 9},
  pages={1039-45}
}
OBJECTIVE In vitro expansion is an important step to acquire sufficient cells in human tissue engineering technologies. The high number of chondrocytes needed for human articular cartilage implants requires in vitro expansion of the primary cells, bearing a theoretical risk of in vitro induced changes in the genomes. To gain more insights into this situation, model cultures were prepared and analyzed. DESIGN 25 chondrocyte cell DNA samples from nine donors were analyzed by array comparative… CONTINUE READING