Genomic characterization of liver metastases from colorectal cancer patients

  title={Genomic characterization of liver metastases from colorectal cancer patients},
  author={Jos{\'e} Mar{\'i}a Sayagu{\'e}s and Lu{\'i}s Antonio Corchete and Mar{\'i}a Laura Guti{\'e}rrez and Mar{\'i}a Eugenia Sarasquete and Mar{\'i}a del Mar Abad and Oscar Bengoechea and Encarna Fermi{\~n}{\'a}n and Mar{\'i}a Fernanda Anduaga and Sof{\'i}a Del Carmen and Manuel Iglesias and Carmen Esteban and Mar{\'i}a Angoso and Jos{\'e} Antonio Alc{\'a}zar and Jacinto Garc{\'i}a and Alberto Orfao and Lu{\'i}s Mu{\~n}oz-Bellv{\'i}s},
Metastatic dissemination is the most frequent cause of death of sporadic colorectal cancer (sCRC) patients. Genomic abnormalities which are potentially characteristic of such advanced stages of the disease are complex and so far, they have been poorly described and only partially understood. We evaluated the molecular heterogeneity of sCRC tumors based on simultaneous assessment of the overall GEP of both coding mRNA and non-coding RNA genes in primary sCRC tumor samples from 23 consecutive… CONTINUE READING
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