Genomic characterization of a cell-culture-adapted Korean human G9P[8] rotavirus, CAU05-202

Abstract

The human rotavirus G9 strain is the fifth most common rotavirus worldwide. A human rotavirus G9P[8] strain CAU05-202 was isolated from a young child with diarrhea using a cell culture system, and its major gene sequences were determined. Phylogenetic analysis of the VP7 gene revealed that CAU05-202 clustered into genetic lineage III-d and was most closely related to G9 rotaviruses from Turkey (strain GUH13) and Sri Lanka (strain 05SLC056 and 05SLC057). VP4 and NSP4 gene analysis showed that CAU05-202 belongs to the P[8]-3 lineage and genotype B, respectively. In addition, CAU05-202 has a long RNA electropherotype, supported by VP6 gene analysis, which is clearly associated with subgroup II specificity. Analysis of the G9 rotavirus strain CAU05-202 provides information concerning the genetic relationships among global rotavirus G9 strains, suggesting that closely related G9 strains are persistent and widespread in Asian countries.

DOI: 10.1007/s00705-012-1232-z

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@article{Shin2012GenomicCO, title={Genomic characterization of a cell-culture-adapted Korean human G9P[8] rotavirus, CAU05-202}, author={Jong Wook Shin and Van Phan Le and Van Thai Than and Inseok Lim and Yoosik Yoon and Kijeong Kim and Sang-in Chung and Soon Chul Myung and Won Yong Kim}, journal={Archives of Virology}, year={2012}, volume={157}, pages={753-759} }