Genomic characterization of POS5, the Saccharomyces cerevisiae mitochondrial NADH kinase.

@article{Shianna2006GenomicCO,
  title={Genomic characterization of POS5, the Saccharomyces cerevisiae mitochondrial NADH kinase.},
  author={Kevin V. Shianna and Douglas A. Marchuk and Micheline K. Strand},
  journal={Mitochondrion},
  year={2006},
  volume={6 2},
  pages={94-101}
}
Disruption of the Saccharomyces cerevisiae mitochondrial NADH kinase POS5 increases the mitochondrial mutation rate 50-fold. Whereas most multicellular eukaryotic genomes have one NADH kinase gene, the yeast genome contains three distinct genes encoding NAD/H kinase activity. To determine if all three genes are essential for viability we constructed combinations of gene knockouts. We show that only the pos5Deltautr1Delta combination is synthetically lethal, demonstrating an essential… CONTINUE READING
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