Genomic characterization and embryonic expression of the mouse Bigh3 (Tgfbi) gene.

@article{Schorderet2000GenomicCA,
  title={Genomic characterization and embryonic expression of the mouse Bigh3 (Tgfbi) gene.},
  author={Daniel F Schorderet and Maurice M{\'e}nasche and Sabine Morand and S{\'e}bastien Bonnel and V B{\"u}chillier and D. Marchant and Katya Auderset and Christophe Bonny and M. H. Abitbol and Frances L Munier},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={274 2},
  pages={267-74}
}
Mutations in human BIGH3 (TGFB1), a gene identified after treatment of an adenocarcinoma cell line with TGF-beta, have been observed in patients with granular Groenouw type I, Reis-Bücklers, Thiel-Behnke, Avellino, and Lattice type I and IIIa, six autosomal dominant corneal dystrophies linked to chromosome 5q. In order to gain insight into the physiological role of this gene, we characterized the genomic structure of the mouse Bigh3 and its expression in murine embryos. The gene spans 30 kb on… CONTINUE READING