Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: a novel human procoagulant.

@article{Yuwaraj2001GenomicCL,
  title={Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: a novel human procoagulant.},
  author={S Yuwaraj and Jia-huan Ding and Mingjun Liu and Philip A. Marsden and Gary A. Levy},
  journal={Genomics},
  year={2001},
  volume={71 3},
  pages={330-8}
}
For diseases in which thrombosis plays a pivotal role, such as virus-induced fulminant hepatitis, fetal loss syndrome, and xenograft rejection, the major procoagulant has remained elusive. Here we describe the isolation and functional expression of a distinct human prothrombinase, termed FGL2. The murine fgl2 gene product has been implicated in the pathophysiology of murine fulminant hepatitis. The predicted ORF corresponds to a 439-amino-acid type II integral membrane protein that contains a… CONTINUE READING

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