Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF

  title={Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF},
  author={Vishwanath R. Iyer and Christine E. Horak and Charles S. Scafe and David Botstein and Michael Snyder and Patrick O. Brown},
Proteins interact with genomic DNA to bring the genome to life; and these interactions also define many functional features of the genome. SBF and MBF are sequence-specific transcription factors that activate gene expression during the G1/S transition of the cell cycle in yeast. SBF is a heterodimer of Swi4 and Swi6, and MBF is a heterodimer of Mbp1 and Swi6 (refs 1, 3). The related Swi4 and Mbp1 proteins are the DNA-binding components of the respective factors, and Swi6 may have a regulatory… CONTINUE READING
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