Genomic approaches that aid in the identification of transcription factor target genes.

@article{Kirmizis2004GenomicAT,
  title={Genomic approaches that aid in the identification of transcription factor target genes.},
  author={Antonis Kirmizis and Peggy J. Farnham},
  journal={Experimental biology and medicine},
  year={2004},
  volume={229 8},
  pages={705-21}
}
It is well-established that deregulation of the transcriptional activity of many different genes has been causatively linked to human diseases. In cancer, altered patterns of gene expression are often the result of the inappropriate expression of a specific transcriptional activator or repressor. Functional studies of cancer-specific transcription factors have relied upon the study of candidate target genes. More recently, gene expression profiling using DNA microarrays that contain tens of… CONTINUE READING