Genomic and regulatory characteristics of significant transcription factors in colorectal cancer metastasis

@article{Zhou2018GenomicAR,
  title={Genomic and regulatory characteristics of significant transcription factors in colorectal cancer metastasis},
  author={Bin Zhou and Rui Guo},
  journal={Scientific Reports},
  year={2018},
  volume={8}
}
  • Bin Zhou, Rui Guo
  • Published 1 December 2018
  • Medicine, Biology
  • Scientific Reports
The dysregulation of transcription factors has an important impact on the oncogenesis and tumor progression. Nonetheless, its functions in colorectal cancer metastasis are still unclear. In this study, four transcription factors (HNF4A, HSF1, MECP2 and RAD21) were demonstrated to be associated with the metastasis of colorectal cancer in both RNA and protein levels. To comprehensively explore the intrinsic mechanisms, we profiled the molecular landscape of these metastasis-related transcription… 
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