Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance.

Abstract

MYC overexpression has been implicated in the pathogenesis of most types of human cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene expression. Previously, we have shown that the loss of MYC overexpression is sufficient to reverse tumorigenesis. Here, we show that there is a precise threshold level of MYC expression… (More)
DOI: 10.1158/0008-5472.CAN-07-6192

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