Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors.

@article{Andersen2012GenomicAG,
  title={Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors.},
  author={Jesper B Andersen and Bart Spee and Boris R. A. Blechacz and Itzhak Avital and Mina Komuta and Andrew J. Barbour and Elizabeth A. Conner and Matthew C Gillen and Tania A Roskams and Lewis R. Roberts and Valentina M. Factor and Snorri Thorgeirsson},
  journal={Gastroenterology},
  year={2012},
  volume={142 4},
  pages={1021-1031.e15}
}
BACKGROUND & AIMS Cholangiocarcinoma is a heterogeneous disease with a poor outcome that accounts for 5%-10% of primary liver cancers. We characterized its genomic and genetic features and associated these with patient responses to therapy. METHODS We profiled the transcriptomes from 104 surgically resected cholangiocarcinoma samples collected from patients in Australia, Europe, and the United States; epithelial and stromal compartments from 23 tumors were laser capture microdissected. We… CONTINUE READING

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