Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.


BACKGROUND Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear. METHODS We analyzed the genomes of 200 clinically annotated adult cases of de novo AML, using either whole-genome sequencing (50 cases) or whole-exome… (More)
DOI: 10.1056/NEJMoa1301689


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