Genomic and chromatin signals underlying transcription start-site selection.

@article{Valen2011GenomicAC,
  title={Genomic and chromatin signals underlying transcription start-site selection.},
  author={Eivind Valen and Albin Sandelin},
  journal={Trends in genetics : TIG},
  year={2011},
  volume={27 11},
  pages={475-85}
}
A central question in cellular biology is how the cell regulates transcription and discerns when and where to initiate it. Locating transcription start sites (TSSs), the signals that specify them, and ultimately elucidating the mechanisms of regulated initiation has therefore been a recurrent theme. In recent years substantial progress has been made towards this goal, spurred by the possibility of applying genome-wide, sequencing-based analysis. We now have a large collection of high-resolution… CONTINUE READING