Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes.

@article{Becker2017GenomicAP,
  title={Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes.},
  author={Justin S Becker and Ryan L McCarthy and Simone Sidoli and Greg Donahue and Kelsey E Kaeding and Zhiying He and Shu Lin and Benjamin A Garcia and Kenneth S Zaret},
  journal={Molecular cell},
  year={2017},
  volume={68 6},
  pages={
          1023-1037.e15
        }
}
Heterochromatin is integral to cell identity maintenance by impeding the activation of genes for alternate cell fates. Heterochromatic regions are associated with histone 3 lysine 9 trimethylation (H3K9me3) or H3K27me3, but these modifications are also found in euchromatic regions that permit transcription. We discovered that resistance to sonication is a reliable indicator of the heterochromatin state, and we developed a biophysical method (gradient-seq) to discriminate subtypes of H3K9me3 and… CONTINUE READING
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