Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma.

@article{Lin2015GenomicAF,
  title={Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma.},
  author={De-chen Lin and Liang Xu and Ye Chen and Haiyan Yan and Masaharu Hazawa and Ngan Bao Doan and Jonathan Said and Ling-Wen Ding and Li-zhen Liu and Henry He Yang and Shizhu Yu and Michael Kahn and Dong Yin and H Phillip Koeffler},
  journal={Cancer research},
  year={2015},
  volume={75 9},
  pages={1815-27}
}
PARK2 (PARKIN) is an E3 ubiquitin ligase whose dysfunction has been associated with the progression of Parkinsonism and human malignancies, and its role in cancer remains to be explored. In this study, we report that PARK2 is frequently deleted and underexpressed in human glioma, and low PARK2 expression is associated with poor survival. Restoration of PARK2 significantly inhibited glioma cell growth both in vitro and in vivo, whereas depletion of PARK2 promoted cell proliferation. PARK2… CONTINUE READING
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