Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma.

  title={Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma.},
  author={De-chen Lin and Anand Mayakonda and Huy Q. Dinh and Pinbo Huang and Lehang Lin and Xiaoping Liu and Ling-Wen Ding and Jie Wang and Benjamin P. Berman and Erwei Song and Dong Yin and H Phillip Koeffler},
  journal={Cancer research},
  volume={77 9},
Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diversity was found in all 11 hepatocellular carcinoma cases, with 29% of driver mutations being heterogeneous, including TERT, ARID1A, NOTCH2, and STAG2. Similar with other cancer… CONTINUE READING
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Highresolution characterization of a hepatocellular carcinoma

  • Y Totoki, TatsunoK, S Yamamoto, Y Arai, F Hosoda, S Ishikawa
  • genome. Nat Genet 2011;43:464–9
  • 2017

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

  • CooperCS, R Eeles, WedgeDC, Van LooP, GundemG, LB Alexandrov
  • Nat Genet
  • 2015
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