Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma.

  title={Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma.},
  author={Dechen Lin and A. Mayakonda and Huy Q. Dinh and P. Huang and Le-hang Lin and X. Liu and Lingwen Ding and Jiayin Wang and B. Berman and Erwei Song and D. Yin and H. Koeffler},
  journal={Cancer research},
  volume={77 9},
  • Dechen Lin, A. Mayakonda, +9 authors H. Koeffler
  • Published 2017
  • Medicine, Biology
  • Cancer research
  • Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diversity was found in all 11 hepatocellular carcinoma cases, with 29% of driver mutations being heterogeneous, including TERT, ARID1A, NOTCH2, and STAG2. Similar with other cancer… CONTINUE READING

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