Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma.

@article{Lin2017GenomicAE,
  title={Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma.},
  author={De-chen Lin and Anand Mayakonda and Huy Q. Dinh and Pinbo Huang and Lehang Lin and Xiaoping Liu and Ling-Wen Ding and Jie Wang and Benjamin P. Berman and Erwei Song and Dong Yin and H Phillip Koeffler},
  journal={Cancer research},
  year={2017},
  volume={77 9},
  pages={2255-2265}
}
Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diversity was found in all 11 hepatocellular carcinoma cases, with 29% of driver mutations being heterogeneous, including TERT, ARID1A, NOTCH2, and STAG2. Similar with other cancer… CONTINUE READING
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