Genomic analysis reveals pre- and postchallenge differences in a rhesus macaque AIDS vaccine trial: insights into mechanisms of vaccine efficacy.

@article{Palermo2011GenomicAR,
  title={Genomic analysis reveals pre- and postchallenge differences in a rhesus macaque AIDS vaccine trial: insights into mechanisms of vaccine efficacy.},
  author={Robert E Palermo and Linda J Patterson and Lauri D. Aicher and Marcus J Korth and Marjorie Robert-Guroff and Michael G. Katze},
  journal={Journal of virology},
  year={2011},
  volume={85 2},
  pages={
          1099-116
        }
}
We have employed global transcriptional profiling of whole blood to identify biologically relevant changes in cellular gene expression in response to alternative AIDS vaccine strategies with subsequent viral challenge in a rhesus macaque vaccine model. Samples were taken at day 0 (prechallenge), day 14 (peak viremia), and week 12 (set point) from animals immunized with replicating adenovirus type 5 host range (Ad5hr) recombinant viruses expressing human immunodeficiency virus HIV(env)(89.6P… CONTINUE READING

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WHOLE-BLOOD MICROARRAYS IN RHESUS AIDS VACCINE TRIAL 1113 on O cber 18, 2017 by gest http/jvi.asm .rg/ D ow nladed fom Peyerl

  • D. H. Barouch, J. Kunstman, M. J. Kuroda, J. E. Schmitz, F.W.S. Santra
  • Nature
  • 2011
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