Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture

@article{Jothi2009GenomicAR,
  title={Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture},
  author={R. Jothi and Santhanam Balaji and Arthur Wuster and Joshua A. Grochow and J{\"o}rg Gsponer and Teresa M. Przytycka and L. Aravind and M. Madan Babu},
  journal={Molecular Systems Biology},
  year={2009},
  volume={5},
  pages={294 - 294}
}
Although several studies have provided important insights into the general principles of biological networks, the link between network organization and the genome-scale dynamics of the underlying entities (genes, mRNAs, and proteins) and its role in systems behavior remain unclear. Here we show that transcription factor (TF) dynamics and regulatory network organization are tightly linked. By classifying TFs in the yeast regulatory network into three hierarchical layers (top, core, and bottom… CONTINUE READING

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