Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus.

@article{Howden2008GenomicAR,
  title={Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus.},
  author={Benjamin P Howden and Timothy P Stinear and David L. Allen and Paul D R Johnson and Peter R. B. Ward and John K. Davies},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 10},
  pages={3755-62}
}
Methicillin-resistant Staphylococcus aureus (MRSA), once restricted to hospitals, is spreading rapidly through the wider community. Resistance to vancomycin, the principal drug used to treat MRSA infections, has only recently emerged, is mainly low level, and characteristically appears during vancomycin therapy (vancomycin-intermediate S. aureus [VISA] and hetero-resistant VISA). This phenomenon suggests the adaptation of MRSA through mutation, although defining the mutations leading to… CONTINUE READING

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