Genomic analysis of the Mozambique strain of Vibrio cholerae O1 reveals the origin of El Tor strains carrying classical CTX prophage.

@article{Faruque2007GenomicAO,
  title={Genomic analysis of the Mozambique strain of Vibrio cholerae O1 reveals the origin of El Tor strains carrying classical CTX prophage.},
  author={Shah M. Faruque and Vincent C. Tam and Nityananda Chowdhury and Pornphan Diraphat and Michelle Dziejman and John F. Heidelberg and John David Clemens and John J Mekalanos and Gopinath Balakrish Nair},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 12},
  pages={5151-6}
}
Cholera outbreaks in subSaharan African countries are caused by strains of the El Tor biotype of toxigenic Vibrio cholerae O1. The El Tor biotype is the causative agent of the current seventh cholera pandemic, whereas the classical biotype, which was associated with the sixth pandemic, is now extinct. Besides other genetic differences the CTX prophages encoding cholera toxin in the two biotypes of V. cholerae O1 have distinct repressor (rstR) genes. However, recent incidences of cholera in… CONTINUE READING

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