Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving.

@article{Sealey2015GenomicAO,
  title={Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving.},
  author={Katie L. Sealey and Simon R. Harris and Norman K Fry and Laurence D. Hurst and Andrew R. Gorringe and Julian Parkhill and Andrew Preston},
  journal={The Journal of infectious diseases},
  year={2015},
  volume={212 2},
  pages={294-301}
}
A major outbreak of whooping cough, or pertussis, occurred in 2012 in the United Kingdom (UK), with nearly 10 000 laboratory-confirmed cases and 14 infant deaths attributed to pertussis. A worldwide resurgence of pertussis has been linked to switch to the use of acellular pertussis vaccines and the evolution of Bordetella pertussis away from vaccine-mediated immunity. We have conducted genomic analyses of multiple strains from the UK outbreak. We show that the UK outbreak was polyclonal in… CONTINUE READING
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