Genomic analyses reveal a conserved glutathione homeostasis pathway in the invertebrate chordate Ciona intestinalis.

@article{Nava2009GenomicAR,
  title={Genomic analyses reveal a conserved glutathione homeostasis pathway in the invertebrate chordate Ciona intestinalis.},
  author={Gerardo M. Nava and David W. Lee and Javier H Ospina and Shi-Ying Cai and H. Rex Gaskins},
  journal={Physiological genomics},
  year={2009},
  volume={39 3},
  pages={183-94}
}
The major thiol redox buffer glutathione (l-gamma-glutamyl-l-cysteinylglycine, GSH) is central to cell fate determination, and thus, associated metabolic and regulatory pathways are exquisitely sensitive to a wide range of environmental cues. An imbalance of cellular redox homeostasis has emerged as a pathologic hallmark of a diverse range of human gene-environment disorders. Despite the central importance of GSH in cellular homeostasis, underlying genetic regulatory pathways remain poorly… CONTINUE READING
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