Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer.

@article{HeselmeyerHaddad2005GenomicAO,
  title={Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer.},
  author={Kerstin Heselmeyer-Haddad and K. Sommerfeld and Nicole M White and Nadia Chaudhri and Larry E Morrison and Nallasivam Palanisamy and Zhen Y. Wang and Gert Auer and Winfried Steinberg and Thomas Ried},
  journal={The American journal of pathology},
  year={2005},
  volume={166 4},
  pages={
          1229-38
        }
}
Invasive cervical carcinomas almost invariably carry extra copies of chromosome arm 3q, resulting in a gain of the human telomerase gene (TERC). This provided the rationale for the development of a multicolor fluorescence in situ hybridization (FISH) probe set as a diagnostic tool for the direct detection of TERC gains in Pap smears. We previously used this probe set to show that cervical intraepithelial neoplasia (CIN) 2 and CIN3 lesions could be distinguished from normal samples, atypical… CONTINUE READING
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