Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma

@article{Miller2006GenomicAO,
  title={Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma},
  author={Charles T. Miller and L Lin and Anne M Casper and J Lim and Dafydd Gareth Thomas and Mark B. Orringer and Andy C-M Chang and Ann F. Chambers and Thomas J. Giordano and Thomas W. Glover and D G Beer},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={409-418}
}
Esophageal adenocarcinoma (EA) is characterized by a poor prognosis making the identification of clinically targetable proteins essential for improving patient outcome. We report the involvement of multiple alterations of the MET pathway in EA development and progression. Microarray analysis of Barrett's metaplasia, dysplasia, and EA revealed overexpression of the MET oncogene in EAs but only those with MET gene amplification. STS-amplification mapping revealed that the boundary of the MET… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 74 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Nat Rev Cancer

  • L Trusolino, Pm Comoglio
  • Nat Rev Cancer
  • 2002
Highly Influential
6 Excerpts

J Cell Biochem

  • Yw Zhang, Vande Woude, Gf
  • J Cell Biochem
  • 2003
Highly Influential
1 Excerpt

Embo J

  • L Naldini, Km Weidner, E Vigna, G Gaudino, A Bardelli, C Ponzetto
  • EMBO J
  • 1991
Highly Influential
3 Excerpts

Cancer Cell

  • Yw Zhang, C Graveel, N Shinomiya, Vande Woude, Gf
  • Cancer Cell
  • 2004

Nat Rev Mol Cell Biol

  • W Guo, Fg Giancotti
  • Nat Rev Mol Cell Biol
  • 2004

Clin Cancer Res

  • Ct Miller, Jr Moy, L Lin, M Schipper, D Normolle, De Brenner
  • Clin Cancer Res
  • 2003

Cytogenet Genome Res

  • Mf Arlt, Am Casper, Tw Glover
  • Cytogenet Genome Res
  • 2003
2 Excerpts

J Biol Chem

  • Eh Sage, M Reed, Se Funk, T Truong, M Steadele, P Puolakkainen
  • J Biol Chem
  • 2003

Proc Natl Acad Sci

  • A Matsuyama, T Shiraishi, F Trapasso, T Kuroki, H Alder, M Mori
  • Proc Natl Acad Sci
  • 2003

Cancer Genet Cytogenet

  • C Rosenberg, E Geelen, Mj Ijszenga, P Pearson, Hj Tanke, Wn Dinjens
  • Cancer Genet Cytogenet
  • 2002
2 Excerpts

Similar Papers

Loading similar papers…