Genomic alterations in lung adenocarcinoma.

  title={Genomic alterations in lung adenocarcinoma.},
  author={Siddhartha Devarakonda and Daniel Morgensztern and Ramaswamy Govindan},
  journal={The Lancet. Oncology},
  volume={16 7},
Treatment for non-small-cell lung cancer is evolving from the use of cytotoxic chemotherapy to personalised treatment based on molecular alterations. This past decade has witnessed substantial progress in the treatment of patients with EGFR mutations and ALK rearrangements, and it is now possible to study complex genomic alterations in cancer using next-generation sequencing. Sequencing data from large-scale consortia, such as The Cancer Genome Atlas, as well as several independent groups, have… CONTINUE READING
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