Genomic alterations and phenotype of large compared to small high-grade ductal carcinoma in situ.

@article{Hwang2011GenomicAA,
  title={Genomic alterations and phenotype of large compared to small high-grade ductal carcinoma in situ.},
  author={E. Shelley Hwang and Aseem Lal and Yunn-Yi Chen and Sandy Devries and Rebecca S Swain and Joe Anderson and Ritu P. Roy and Frederic M. Waldman},
  journal={Human pathology},
  year={2011},
  volume={42 10},
  pages={1467-75}
}
A clinically distinct subgroup of pure ductal carcinoma in situ presents as an extensive, high-grade lesion, which nevertheless lacks invasion. We sought to evaluate differences between those ductal carcinomas in situ presenting as large versus small lesions while controlling for high-grade, to determine whether there exist phenotypic and genetic differences between the 2 groups. Fifty-two cases of pure high-grade ductal carcinomas in situ were collected retrospectively, consisting of 27 large… CONTINUE READING