Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model.

@article{Notini2005GenomicAO,
  title={Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model.},
  author={Amanda J. Notini and Rachel A. Davey and Julie F McManus and Kendall Bate and Jeffrey Zajac},
  journal={Journal of molecular endocrinology},
  year={2005},
  volume={35 3},
  pages={
          547-55
        }
}
Androgens mediate their effects in target cells via the androgen receptor (AR), which acts predominantly as a ligand-dependent transcription factor. In addition, androgens induce rapid activation of second messenger signal transduction cascades, and this is thought to occur via non-genomic mechanisms. We have used the Cre/loxP system to generate an AR knockout (ARKO) mouse targeting exon 3, which encodes the second zinc finger of the DNA-binding domain. To generate universal ARKO mice, floxed… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 70 CITATIONS, ESTIMATED 42% COVERAGE

Androgen receptor action in osteoblasts in male mice is dependent on their stage of maturation.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2015
VIEW 6 EXCERPTS
CITES RESULTS, METHODS & BACKGROUND

Mineralization and bone resorption are regulated by the androgen receptor in male mice.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2009
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND

Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2008
VIEW 7 EXCERPTS

FILTER CITATIONS BY YEAR

2006
2018

CITATION STATISTICS

  • 14 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 3 EXCERPTS

Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 1 EXCERPT

Late onset of obesity in male androgen receptor-deficient (AR KO) mice.

  • Biochemical and biophysical research communications
  • 2003
VIEW 1 EXCERPT

Suppressive function of androgen receptor in bone resorption.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
VIEW 1 EXCERPT

The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases

CC Linder
  • Lab Animal
  • 2001
VIEW 1 EXCERPT