Genomic Targets of Brachyury (T) in Differentiating Mouse Embryonic Stem Cells

  title={Genomic Targets of Brachyury (T) in Differentiating Mouse Embryonic Stem Cells},
  author={Amanda Littlewood Evans and Tiago Faial and Michael J Gilchrist and Thomas Down and Ludovic Vallier and Roger A. Pedersen and Fiona C. Wardle and James C Smith},
  booktitle={PloS one},
BACKGROUND The T-box transcription factor Brachyury (T) is essential for formation of the posterior mesoderm and the notochord in vertebrate embryos. Work in the frog and the zebrafish has identified some direct genomic targets of Brachyury, but little is known about Brachyury targets in the mouse. METHODOLOGY/PRINCIPAL FINDINGS Here we use chromatin immunoprecipitation and mouse promoter microarrays to identify targets of Brachyury in embryoid bodies formed from differentiating mouse ES… CONTINUE READING

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